- Sam Holliday – Fountain Inn – 20-28 186 yards 1 TD, 19 rushes 177 yards 1 TD
- Triston Lewis – Greenwood – 24-39 423 yards 5 TDs, 18 rushes 70 yards 1 TD
- Trey Crawford – Greenwood – 15 rushes 176 yards
- Muntu Brown – Wren – 30 rushes 191 yards 4 TDs
- Hunter O’Neal – Keenan – 34 rushes 426 yards 5 TDs
- Jay Duncan – Greenwood – 13 rec 167 yards 3 TDs
- Brian McMillan – Bamberg-Ehrhardt – 122 passing yards 1 TD, 88 rushing yards 2 TDs, 5 T, 1 INT
- Jalen McGraw – Bamberg-Ehrhardt – 147 rush yards 1 TD, 10 T, 2 Sacks
- Charles Anthony Williams – Bamberg-Ehrhardt – 5 rec 86 yards 1 TD
- Daren Sease – Bamberg-Ehrhardt – 15 T, 2 TFL
- Bryce Adams – Chesterfield – 18-24 217 3 TDs, 1 rec 65 yards, 5 rushes 54 yards 2 TDs
- Greg Rushing Jr – Chesterfield – 21 rushes 151 yards 2 TDs
- Jullian McClain – Chesterfield – 15 rushes 103 yards
- Mark Moten – Chesterfield – 2 rushes 6 yards 1 TD
- Holden Lowery – Chesterfield – 4 rec 69 yards 1 TD
- Emani Welch – Chesterfield – 5 rec 134 yards 1 TD
- Sincere Hubbard – Chesterfield – 3 rec 33 yards 1 TD
- Aedan McCarthy – Bluffton – 18-28 459 yards 4 TDs
- Carnell Warren – Bluffton – 6 rec 173 yards 2 TDs
- Amare Patterson – Bluffton – 3 rec 161 yards 2 TDs
- Ryan Von Wyl – Christ Church – 4-5 PAT, 1-1 FG, 35-yard FG game-winner as time expired
- Jaiden Bryant – Irmo – 14 T, 3 Sacks, 3 TFL, 1 INT for TD, 1 FR for TD, 3 PBU
- Trenton Lynch – Spartanburg – 8 rushes 160 yards 3 TDs, 1 rec 48 yards 1 TD
- Nick Gordon – Cheraw – 9 rec 118 yards, 168 APY
- Michael Martin – Christ Church – 3 TDs
- Nick Means – Dorman – 20 rushes 163 yards 4 TDs
- Isaac Tate – Dorman – 10 rushes 146 yards 2 TDs
- Ant Atkins – Christ Church – 1 TD, 1 FR
- Javen Cook – Clinton – 10 rushes 103 yards 1 TD
- Kenton Caldwell – Newberry – 19-22 199 yards 2 TDs, 22 rushes 219 yards 4 TDs
- Jakari Holloman – Central – 6 T, 1 FF, 2 rushes 107 yards 2 TDs
- Aiden Short – Central – 15 rushes 113 yards 1 TD, 2 rec 43 yards 1 TD
- Dwayne Louallen – Central 10-14 153 yards 3 TDs
- Taveon Moore – Central – 4 rec 85 yards 1 TD, 3 T, 1 TFL
- Jamel Howse – Newberry – 9 rec 100 yards 1 TD
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Reggie Shannon – Sumter – 24 rushes 245 yards 4 TDs
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Franklin Richardson – Sumter – 13 rushes 66 yards 4 TDs, 7-11 108 yards
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Javonte Brown – Sumter – 6 T, 2 TFL, 1 Sack
- Cooper Kafina – Summerville – 11-18 250 yards 3 TDs
- Jaiden Kelly-Murray – Summerville – 6 rec 180 yards 2 TDs, 216 APY
- Jayven Williams – Summerville – 2 Rush TDs
- Woodruff Football – 50 unanswered points
- Northwestern Offense – 600+ yards, outscored SF 45-21 after 1Q being down 14-10
- Tylin Drakeford – Camden – 1 Rush TD, 1 Rec TD
- Navi Boykin – Camden – 2 Rushing TDs
- Greyson Rimpf – Camden – 2 Passing TDs
- Jaxon Knotts – Dutch Fork – 17-22 342 APY, 3 Pass TDs, 1 Rush TD
- Stone Furrey – Dutch Fork – 6 rec 158 yards 1 TD
- Matthew Hillstock – Easley – 7 rec 73 yards 2 TDs